Antihypertensive effects of adrenergic β-blocking agents
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چکیده
منابع مشابه
Effects of adrenergic neurone blocking agents on guinea pig ileum.
Sharma and Rajapurkar (~) while studying the actions of adrenergic neurone blocking drugs on intestinal peristalsis observed that bretyliurn and xylocholine in bigger doses produced a stimulant response on the longitudinal moveme-nts of guinea pig ileum where as guanethidine had no stimulant action (unreported observations). Those observations are in consonance witb tbe observations of Boura an...
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Beta receptor adrenergic blocking agents produce a fall of systemic arterial blood pressure which has been attributed to interference with the function of sympathetic nerves to the heart (1). While pronethalol and propranolol are known to have a peripheral vasodilator component of action which contributes to their hypo tensive effect (2, 3), it has not been determined if the more recently synth...
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P atients with established, uncomplicated arterial hypertension are characterized by a normal resting cardiac output and an increased systemic vascular resistance affecting the renal vascular bed most prominently.l-3 The elevated blood pressure can, generally speaking, be lowered by reducing the cardiac output, fower-ing the systemic vascular resistance, or through a combination of both. An ide...
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T HE endogenously released neurotransmitter substance, norepinephrine, or an injected sympathomimetic amine, ultimately exerts its actions on an organ system by combining with an area of the effector cell termed the adrenergic “receptor site.” That drugs and neural chemical mediators react with specific receptors in living tissues was suggested by Langley”” in 1905, who suggested that effector ...
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Cardiac dysfunction in heart failure is widely recognized as a progressive process, regardless of the clinical signs and symptoms. An increase in cardiac sympathetic drive is one of the earliest neurohormonal responses occurring in patients with heart failure and may be one of the major causes of the progressive remodeling leading to the decline in myocardial function, and responsible for the p...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1978
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)53093-1